"What's the best way to make ISK in Eve?" Go mow your neighbors lawn and use that money to buy PLEX. Fundamentally you exchange your time for ISK. If maximum ISK is the goal then get a RL job and use your credit card. A better question to ask might be "What do I enjoy doing in Eve?". Once you have that answer then go do it. Time is our only true currency. Use it wisely.

After getting frustrated trying to find a corporation that worked for him, Andurula did what any sensible Caldari citizen would do, he started one. When not engaged at the corporate desk, Andurula can usually be found managing his planetary colonies or hauling for his corporation.