Harkonnen, was a Great House of the Landsraad whose capital resided on the heavily industrialized world of Giedi Prime. Historical enemies of House Atreides since the Battle of Corrin, the Harkonnens earned a notorious reputation for underhanded and sinister political tactics fueled by their ambition, malevolence, hatred and brutality.

Typically ruled by a Siridar-Baron, House Harkonnen was essentially annihilated after the Battle of Arrakeen, though its family line continued on Giedi Prime throughout the entire reign of the Atreides Empire.