The Empire of Kilrah, also known as the Kilrathi Empire was the political body which ruled over the Kilrathi. It was a militaristic expansionist power that sought to establish Kilrathi dominance over the known galaxy. Its former capital was the Kilrathi homeworld, Kilrah.

The Empire of Kilrah collapsed in 2669 when a small strike force of elite Terran pilots deployed the Temblor Bomb to Kilrah, destroying the Imperial seat of the Empire and killing billions of Kilrathi. The destruction of the Kilrathi homeworld left the Empire of Kilrah in ruins, forcing the Kilrathi to surrender to the Confederation and ending their Imperialist campaign across the galaxy. The remnants of the shattered empire have slowly begun to emerge centuries after the dark age.